Polyamines

The gut is a crucial organ liable for digestion, absorption, and metabolism of dietary nutrients. The mucosa of the gastrointestinal (GI) tract is lined with epithelium that has the shortest employee turnover of any tissue within the body. Maintenance of GI epithelial homeostasis depends on a posh interplay between processes involving intestinal somatic cell (IEC) proliferation, differentiation, migration, and apoptosis. Under normal physiological situations, undifferentiated epithelial cells continuously replicate within the proliferative zone within the crypts and differentiate as they migrate up towards the luminal surface of the colon and villous tips within the intestine. To take care of a stable number of enterocytes, cellular division must be counterbalanced by the method of apoptotic necrobiosis, a fundamental organic process involving selective cell deletion to manage tissue homeostasis. Apoptosis occurs within the crypt area, where it maintains a critical balance in cell number between newly divided and surviving cells, and at the luminal surface of the colon and villous tips within the intestine, where differentiated cells are lost. This rapid dynamic employee turnover of intestinal epithelial cells is very regulated and critically controlled by numerous factors, including cellular polyamines

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