Spine Research

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Peer Review Journals On Osteomalacia

Osteomalacia means soft bones. Bone may be a living, active tissue that’s continually being removed and replaced. This process is understood as bone turnover. Bone consists of a tough outer shell (the cortex) made from minerals, mainly calcium and phosphorus, and a softer inner mesh (the matrix) made from collagen fibres.

When normal bone is made , these fibres are coated with mineral. This process is named mineralisation. The strength of the new bone depends on the quantity of mineral covering the collagen matrix. The more mineral laid down, the stronger the bone. Osteomalacia happens if mineralisation doesn’t happen properly. In osteomalacia more and more bone is formed from collagen matrix without a mineral covering, therefore the bones become soft. These softened bones may bend and crack, and this will be very painful. There are rarer sorts of osteomalacia. These are usually thanks to problems within the kidneys which end in loss of phosphorous from the body. this is often sometimes inherited and passed from parents to their children in their genes, but also can happen with other kidney problems and occassionally as a side effect of treatment with some drugs.

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