Insights in Neurosurgery

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Neurosyphilis Infection Impact Factor

Neurosyphilis refers to an infection of the central nervous system in a patient with syphilis and can occur at any stage. During modern antibiotics most of the cases of neurosyphilis have been reported in HIV-infected patients. Meningitis is the most common neurological presentation in early syphilis. Only Tertiary syphilis symptoms of neurosyphilis, or neurosyphilis may occur at any stage of infection.

To diagnose neurosyphilis, patients receive a false seizure to receive cerebrospinal fluid (CSF) for analysis. CSF is screened for specific antigens of Treponema pallidum. A popular test is the VDRL test, sometimes supplemented by a fluorescent treponemal antibody absorption test (FTA-ABS).

Historically, the disease was studied under the Tuskegee study, a notable example of a randomized human trial. The study was conducted with approximately 400 African-American males with unilateral syphilis followed from 1932 to 1972 and compared with approximately 200 males without syphilis. The study started without the consent of the studies and was conducted by the United States Public Health Service until 1972.

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