Neurofibromatosis (NF) is one of the most common genetic disorders, with a frequency of nearly 1 in 3,000 live births. 1 Inherited in an autosomal dominant pattern, with variable penetrance, neurofibromatosis is readily subdivided into two subtypes based on gene locus and associated characteristics. Von Recklinghausen’s disease, or neurofibromatosis type 1 (NF1), is the more common and recognizable of the two types and has been localized to the long arm of chromosome 17. 2 , 3 NF1 has been a well-documented and described disease process since 1882, when it was first described by Friedrich von Recklinghausen. 4 Neurofibromatosis type 2 (NF2) is much less common, with a frequency of 1 in 55,000 live births, and was first characterized in the 1930s. This form is localized to the long arm of chromosome 22 and was not considered a separate disease entity until 1981. 5 , 6 Other subtypes of neurofibromatosis have been suggested, but these have not been universally accepted because discrete genetic markers and patterns have not been identified.
Posters & Accepted Abstracts: Annals of Clinical and Laboratory Research
Posters & Accepted Abstracts: Annals of Clinical and Laboratory Research
ScientificTracks Abstracts: Journal of Clinical & Experimental Orthopaedics
ScientificTracks Abstracts: Journal of Clinical & Experimental Orthopaedics