Atherosclerosis is a chronic inflammatory lipid-fueled disease of the arteries that is initiated very early in childhood and mediated by innate and adaptive immune responses. Atherosclerosis is characterized by progressive accumulation of lipids, necrotic cell debris, and extracellular matrix proteins in the vessel wall and eventually results in partial or total vessel occlusion or thrombosis due to rupture or erosion of the atherosclerotic plaque. Atherosclerosis reveals itself clinically later in life and is influenced by genetic, environmental, behavioral, and dietary risk factors [1–3]. The risk factors for atherosclerosis include hypercholesterolemia, diabetes, cigarette smoking, and hypertension. Hypercholesterolemia, for instance, increases the permeability of the vessel walls and initiates the pathogenesis of the disease [4]. The Framingham study showed that low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C) are the major independent predictors of future atherosclerotic events [4]. The need to pinpoint further causal risk factors and thus prospective targets for future interventions is evident [5] by the fact that atherosclerosis is the still the principal cause of cardiovascular disease (CVD) death worldwide despite the decline in mortality rate due to advances in its diagnosis, treatment, prevention, and rehabilitation [6, 7]. Currently, lipoprotein(a) [Lp(a)], aka “Lp little a”, is taken into account a possible candidate and independent strong predictor of atherosclerosis.
Editorial: Annals of Biological Sciences
Editorial: Annals of Biological Sciences
Research Article: Annals of Biological Sciences
Research Article: Annals of Biological Sciences
Research Article: Annals of Biological Sciences
Research Article: Annals of Biological Sciences
Research Article: Annals of Biological Sciences
Research Article: Annals of Biological Sciences
Research Article: Annals of Biological Sciences
Research Article: Annals of Biological Sciences
Posters & Accepted Abstracts: Annals of Biological Sciences
Posters & Accepted Abstracts: Annals of Biological Sciences
Keynote: Annals of Biological Sciences
Keynote: Annals of Biological Sciences
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