Journal of Chemical Biology & Pharmaceutical Chemistry

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Hydrolysis

Hydrolysis involving organic compounds could also be illustrated by the reaction of water with an ester of a carboxylic acid; all such esters have the overall formula RCO―OR′, during which R and R′ are combining groups (for example, if R and R′ both represent the methyl , CH3, the ester is methyl acetate). The hydrolysis involves several steps, of which the slowest is that the formation of a chemical bond between the oxygen atom of the water molecule and therefore the atom of the ester. In succeeding steps, which are very rapid, the carbon–oxygen bond of the ester breaks and hydrogen ions become detached from the first water molecule and attached to the nascent alcohol molecule.

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