Dieulafoy’s lesion (DL) is an abnormal arterial lesion within the alimentary canal. These lesions account for up to five of acute upper gastrointestinal haemorrhages. The stomach is that the most often comprised, around 75% of all cases. The classic site is that the proximal lesser curvature within 6 cm of the gastroesophageal junction and accounts for about 65% of the gastric lesions. The duodenum is that the second commonest site for DL and over half the DL encountered within the duodenum occurs within the bulb. We report a 21-year-old male, with none relevant his past medical and familiar history. He admitted to the ER with a 3 hours history of hematemesis and melena. His physical examination showed a, pulse of 89 bpm, vital sign 110/60, no orthostatism, abdominal examination showed a non-distended abdomen with slight epigastric pain, and no organomegaly. The cardiovascular, respiratory and neurological examinations were unchanged. The laboratory results showed: Hemoglobin: 11.1 gr/dl, WBC count: 8900 cells/mm3, platelets count: 235,000, LFTs: normal. Abdominal US and a clear abdominal X-ray were also normal. An upper endoscopy showed a protruding vessel without surrounding venous dilatation, active bleeding or mucosal defect. This vascular lesion was located within the anterior wall of duodenal bulb.