New drug discovery is a complex process involving the inputs of many branches of science like, physical and organic chemistry, cellular and molecular biology, biochemistry, pharmacology, computational chemistry, and so on and so forth. Discovering a new drug molecule and bringing it to the clinician's desk requires team efforts of so many experts in their own field. When we peep into the past we notice that new drugs have been discovered either serendipitously or by keen observations and systematic studies. Upto 1980s the rate of launching new drug molecules per year has remained impressive but 1990 onwards this rate has decreased dramatically. Medicinal chemists became more rational in their approach in the later years for discovering new drugs and that should have increased the rate of discovering new drug molecules over the years. But astonishinglythe reverse has happened. One understandable reason is a stricter regulatory regime which is more sensitive to the reporting of side effects of the new drugs and providing of exhaustive pre-clinical and clinical data.