Insights in Chest Diseases

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Asthma Genetics Syndrome Scientific Journals

Asthma and allergic diseases are complex conditions caused by a mixture of genetic and environmental factors. More than 100 genes have been associated with asthma and related conditions. Allergic asthma has been called a “syndrome” resulting from a posh interplay between genetic and environmental factors. Genetic differences may alter susceptibility to asthma, also as responsiveness to asthma medications. Significant genetic variation exists between and within racial and ethnic groups, but the difficulty is confounded by important coexisting economic, cultural, and environmental differences, including geography. A few previously suspected genetic variants are confirmed in these studies as asthma susceptibility loci, or as loci contributing to disease severity or response to treatment. Scholarly journal may be a peer-reviewed journal during which scholarship concerning a specific academic discipline is published. Scholarly journals function forums for the introduction and presentation for scrutiny of latest research, and therefore the critique of existing research. Content typically takes the shape of articles presenting original research, review articles, and book reviews
Asthma is a complex disease with a phenotype that has been clinically difficult to define. Associated phenotypes including bronchial hyperresponsiveness and atopy have provided useful objective alternatives in genetic and epidemiologic studies. Although asthma genes have not yet been identified, much progress has been made toward this goal. Genetic studies indicate that multiple genes are involved in the pathogenesis of this disease, and chromosomal regions likely to harbor asthma susceptibility genes have been replicated in several studies. Environmental factors, including smoking, diet, and viral respiratory infections, have also been implicated within the etiology of asthma. Directly linking these exposures as causes of asthma, however, has also proved difficult. Furthermore, interaction between susceptibility genes and environmental factors is probable and should be a challenge currently being pursued by investigators worldwide. Understanding the elemental gene-environmental interactions within the development of asthma should cause earlier identification of susceptible individuals and simpler approaches for disease prevention.

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Citations : 60

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