Diabetes Care and Treatment

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Articles On Glucose Metabolism Disorders

New-onset DM , clinically almost like type 2 diabetes, will affect alittle proportion (1%–6%) of patients infected with human immunodeficiency virus (HIV) who are treated with HIV-1 protease inhibitors (PIs). However, insulin resistance and impaired glucose tolerance will develop during PI treatment during a considerable proportion of patients. Dyslipidemia, abdominal obesity, and loss of peripheral fat frequently coexist with insulin resistance, but it's not clear whether all of those result from a standard pathogenic mechanism. Recent data suggest that insulin resistance can also be related to HIV infection in patients not receiving PI therapy. The long-term consequences of insulin resistance during this population aren't known. The effect of switching to other antiretroviral therapies has not been fully determined. Treatment of established DM should generally follow existing guidelines. there's no clinically useful screening test which will determine the existence and degree of insulin resistance in individual patients. it's therefore reasonable to recommend general measures to extend insulin sensitivity altogether patients infected with HIV, like weight reduction for obese persons and regular aerobics .

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