Antiretroviral therapy has transformed HIV into a chronic condition for those with access to treatment. Despite this clinical success, dealing with the diagnosis and progression of the virus poses enormous psychiatric challenges which will exacerbate or cause mental depression. Studies show that folks living with HIV experience depression at rates twice or quite that of uninfected individuals. Physical, psychological and social dysfunctions resulting from white plague can increase the strain of living with HIV, accelerating the deterioration of mental health. Depression, in turn, is related to poorer biological responses, faster clinical progression and better mortality among people living with the virus. As per available reports about 66 journals, 90 Conferences, 50 workshops are presently dedicated exclusively to Antiquity and about 7226 articles are being published on the topic Antiretroviral Therapy. In terms of research annually, USA, India, Japan, UK, Ireland and Kenya are a number of the leading countries where maximum studies associated with Antiretroviral Therapy are being administered.