International Journal of Drug Development and Research

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Anti-Apoptotic Drug

The main problem with most chemotherapy drugs is their lack of choice. They attack and kill not only the cancer of the womb, but in many cases also normal cells in the tissue that are essential for the survival of cancer patients. Drugs that target the function of cells that are important for cancer cell survival should benefit the cancer patient receiving chemotherapy. The cancer cells have developed many strategies to avoid apoptosis, or programmed cell death. The BCL-2 family contains anti-apoptotic and pro-apoptotic proteins. The anti-apoptotic family protein BCL-2 is linked to the survival of pathogenic cells including cancer cells. RNA inhibition has been one mechanism to suppress anti-apoptotic BCL-2 and cell cancer survival. However, there is a question about the efficacy of siRNA in silencing long genes. One approach that has evolved to alter, positively or negatively, the apoptotic signaling protein function is the use of fixed peptides.

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