The future of individuals living with the Human Immunodeficiency Virus (HIV) has significantly improved with the much-expanded access to antiretroviral treatment. Thus, a bigger number of individuals living with HIV are living longer and confronting the expanded weight of non-transferable ailments. This examination surveyed the impact of incessant non-transferable disease(s) and co-morbidities on the immunologic reclamation of HIV tainted patients on profoundly dynamic antiretroviral therapy. A settled case-control study was led among individuals living with HIV at Jimma University Medical Center from February 20 to August 20, 2016. Cases were HIV tainted patients living with incessant non-transmittable maladies and controls were individuals living with HIV as it were. Quiet explicit information were gathered utilizing an organized information assortment device to distinguish applicable data. Information was examined utilizing the Statistical Package for Social Science adaptation 20.0. Strategic relapses were utilized to distinguish factors related to result. Factual noteworthiness was considered at p-esteem <0.05. A patient's composed educated assent was acquired in the wake of clarifying the reason for the investigation.