The discovery of the human immunodeficiency virus (HIV) as the causative organism of acquired immunodeficiency syndrome (AIDS) and the lack of ability of cutting-edge medication to find a cure for it has placed HIV as one of the most dreaded pathogens of the twenty first century. With hundreds of thousands of humans infected with HIV, it turned into as soon as notion to result in “medical apocalypse”. However, with the arrival of antiretroviral remedy (ART), it is now feasible to govern HIV. Adherence to ART allows to keep the viral load below control and prolong the time of development to AIDS, resulting in close to regular life expectancy. Even with the advent of ART, a massive range of sufferers fail to adhere because of a selection of reasons, along with adverse side consequences, drug abuse, mental disorders, socioeconomic popularity, literacy, and social stigma. With the supply of such a lot of alternatives for HIV remedy at every stage of the ailment progression, physicians can transfer among the treatment regimens to keep away from and/or reduce the destructive consequences of medicine. Close tracking, major social reforms, and good enough counseling ought to also be applied to bypass different demanding situations.