Paraneoplastic syndrome is defined as a disorder which arises as tumour secretion of hormones, peptides, cytokinnin. Malignancies include small lung cancers, gynaecologic tumours, hematologic problems.The concept that malignant disease can cause damage to the nervous system above and beyond that caused by direct or metastatic infiltration is familiar to all clinicians looking after cancer patients. These “remote effects” or paraneoplastic manifestations of cancer include metabolic and endocrine syndromes such as hypercalcaemia, and the syndrome of inappropriate ADH (antidiuretic hormone) secretion

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