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World Nutrition 2018
J u n e 1 8 - 1 9 , 2 0 1 8
P a r i s , F r a n c e
Page 41
Journal of Clinical Nutrition & Dietetics
ISSN 2472-1921
W o r l d C o n g r e s s o n
Nutrition and Dietetics
Background:
Obesity is highly influenced by complex gene-environment
interactions. New challenges in obesity research are currently focused on
personalizing nutrition recommendations by better adapting them to the
nutritional requirements and metabolism of the individual. To save both time
and efforts for the individuals with overweight or obesity and dieticians,
prescribing a once-for-all individually customized nutrition regime instead
of a one-for-all population-based perspective would be a key approach. The
concept of nutrigenomics in dietetic counselling is hypothesized in theory to
help on deciding the most appropriate level of nutrition care through being
based on the individual’s obesity genotype/phenotype. In this context, the aim
of this pilot project was to evaluate the effectiveness of genetically tailored
dietary and lifestyle recommendations in dietetic practice for optimizing
weight loss outcomes.
Materials & Methods:
Overweight-to-obese patients, with a history of
unsuccessful weight loss attempts, were experimentally counselled based
on a commercially available genetic test screening 8 single nucleotide
polymorphisms (SNP) in 7 obesity-associated genes. Bioelectrical impedance
analysis (BIA) was used to measure body weight and composition. The change
in body weight and composition measurements between the beginning and
end of the pilot was analysed. In addition, the effectiveness of the genetically
tailored counselling approach was assessed.
Results:
15 out of 36 patients were found to be previously following the
wrong matching diet according to their genetic profile screened; 11 of which
achieved the highest weight loss outcomes. Those results reflected in a highly
significant loss in body weight and subsequent BMI (p<0.001), where the Body
Mass Index (BMI) mean decreased by more than one unit from 35.433 to
34.419 kg/m
2
in a 3-month period. In addition, the mean decrease in fat mass,
fat mass percentage, and visceral fat area was highly significant (p<0.001) and
the mean of the waist-to-hip ratio also decreased significantly (p<0.05).
Conclusion:
Management of obesity by personalizing dietary and lifestyle
recommendations based on genetic profiles offers promise in practice as in
theory.
Biography
Cynthia Issa has completed her Bachelor’s degree in Nutrition
and Dietetics at Beirut Arab University in Lebanon and became
Lecturer of Clinical and Therapeutic nutrition for more than a
year as a reward of graduating with a scientific excellence
award. She completed her Master’s studies in Life sciences
specialised in Nutrition and Health at Bern University of Applied
Sciences in Switzerland, and worked for 6 months as an Intern
in the Nutrition and Dietetics research team. Currently, she is
applying for her Doctoral studies at the University of Zurich,
Switzerland.
cynthiaissa92@gmail.comManagement of obesity by personalizing dietary and lifestyle
recommendations: evaluation of genetic profiling for weight
loss in dietetic practice
Cynthia Issa and Helena Jenzer
Bern University of Applied Sciences, Switzerland
Cynthia Issa et al., J Clin Nutr Diet 2018 Volume: 4
DOI: 10.4172/2472-1921-C1-002