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Page 42
May 24-25, 2018
London, UK
Vascular Surgery 2018
3 rd Edition of World Congress & Exhibition on
Vascular Surgery
Journal of Vascular and Endovascular Therapy
ISSN: 2573-4482
Aim: Indigenous Australians are at high risk of developing
diabetes-related foot complications requiring major lower limb
amputations. The aim of this study was to assess the incidence
and outcome for Indigenous Australians and non-Indigenous
Australians undergoing major amputations (MA) at the main
tertiary hospital in North Queensland, Australia over a 16-year
period.
Methods: This was a retrospective study assessing all patients
who underwent a MA at The Townsville Hospital between
2000 and 2015. Clinical characteristics were compared using
Pearson’s χ2 test and Mann Whitney U test. MA rates (per
100,000) were calculated using the census data as the standard
population. Kaplan Meier survival analysis and Cox proportional
hazard analysis compared the incidence of all-cause mortality
among both groups.
Results: A total of 374 MA occurred between 2000 and 2015.
Seventy MA occurred in Indigenous Australians and 304
occurred in non-Indigenous Australians. Indigenous patients
were younger (p<0.005), more likely to be females (p=0.002),
have diabetes (p<0.005), end-stage renal failure (p=0.003), and
were more likely to die during follow-up (p=0.028). Overall rates
of MA in Indigenous and non-Indigenous patients with diabetes
were 291.9 and 70.1 per 100,000 respectively. MA rates
increased in Indigenous (~15%) and non-Indigenous patients
(~50%) with diabetes between 2000-2007 and 2008-2015
(p=0.505). Indigenous patients were at a ~2-fold greater risk
of all-cause mortality (p=0.027) compared to non-Indigenous
patients. This association was lost in the multivariate analysis
(HR 1.24 [0.82-1.89], p=0.314).
Conclusion: The burden of MA has increased in North
Queensland and is greater in Indigenous Australians.
Recent Publications
1. Singh T P, Morris D R, Smith S, Moxon J V and Golledge
J (2017) Systematic review and meta-analysis of the
association between C-reactive protein and major
cardiovascular events in patients with peripheral artery
disease. European Journal of Vascular and Endovascular
Surgery 54(2):220-33.
2. Morris D, Singh T, Moxon J, Smith A, Stewart F, Jones
R, et al. (2017) Assessment and validation of a novel
angiographic scoring system for peripheral artery
disease. British Journal of Surgery 104(5):544-54.
3. Singh T P, Vangaveti V N, Kennedy R L and Malabu
U H (2016) Role of telehealth in diabetic foot ulcer
management - a systematic review. Australian Journal
of Rural Health 24(4):224.
4. Nair J J and Singh T P (2017) Sjogren’s syndrome:
Review of the aetiology, pathophysiology & potential
therapeutic interventions. Journal of Clinical and
Experimental Dentistry 9(4):e584-e589.
5. Singh T P, Vangaveti V N and Malabu U H (2015)
Dipeptidyl peptidase-4 inhibitors and their potential
role in the management of atherosclerosis - a review.
Diabetes & Metabolic Syndrome: Clinical Research &
Reviews 9(4):223-9
Biography
Tejas P Singh is a Resident Medical Officer at the Vascular Surgery De-
partment of the Townsville Hospital and a Junior Research Fellow at the
Queensland Centre for Peripheral Vascular Disease
A comparison of major amputation rates and outcomes for
Indigenous and non-Indigenous Australians in a major tertiary
hospital
Tejas P Singh1, 2, Samantha Peden1, Ammarah Tahir1, Vikram Iyer1, 2, Ramesh Velu1,
Joseph V Moxon1, Yvonne Cadet James3 and Jonathan Golledge1, 2
1Queensland Research Centre for Peripheral Vascular Disease - JCU, Australia
2Townsville Hospital, Australia
3James Cook University, Australia
Tejas P Singh et al., J Vasc Endovasc Therapy 2018, Volume 3
DOI: 10.21767/2573-4482-C1-002