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J Obes Eat Disord, 2017
ISSN: 2471-8203
August 23-24, 2017 | Toronto, Canada
allied
academies
INTERNATIONAL OBESITY, BARIATRIC AND
METABOLIC SURGERY SUMMIT AND EXPO
B
ariatric surgery is successful in inducing weight loss in
morbidly obese individuals, but often is complicated by
resultant hematological disorders. Although micronutrient
deficiencies play a significant role, recent studies suggest a
possible role for adipocyte-derived circulating inflammatory
cytokinesandhormonesinthedevelopmentofhematopoietic
abnormalities. The evaluation of anemia and single or
multilineage cytopenias after gastric bypass surgery must
take into account, the unique features of the RYGB clinical
setting. Attention to the time of onset of the cytopenia(s) is
important, because inflammation, drugs and infections are
more likely to occur in the first few months after surgery,
either as the direct agent of marrow suppression or as the
trigger for immune cytopenia(s). Malnutrition including iron,
copper and B
12
deficiencies should always be investigated as
a potential precipitating or aggravating cause of cytopenia(s).
Drug-related anemia and cytopenia(s) due to a variety of
mechanisms, including perturbation of T-cell subsets leading
to autoimmune cytopenia, should also be considered. Early
investigation of the etiology of persistent cytopenia(s) by
diagnostic bone marrow biopsy is warranted, because the
cytopenia conditions usually have a better prognosis if early
interventions are undertaken
e:
myychen@ucdavis.eduHematological disorders following gastric bypass surgery: Emerging concepts of the interplay between
nutritional deficiency and inflammation
Mingyi Chen
UT Southwestern Medical Center, USA
J Obes Eat Disord, 3:2
DOI: 10.21767/2471-8203-C1-003