neurology-2018-keynote

t h

E u r o S c i C o n C o n f e r e n c e o n

Neurology & Neurological

Disorders

Journal of Neurology and Neuroscience

ISSN: 2171-6625

J u l y 1 2 - 1 3 , 2 0 1 8

P a r i s , F r a n c e

Neurology 2018

Page 20

he brain lacks traditional lymphatic vessels. Instead, interstitial fluid is

eliminated along the basement membranes of capillaries and basement

membranes surrounding smooth muscle cells of arteries, towards the surface

of the brain. These intramural periarterial drainage pathways become modified

with ageing, possession of apolipoprotein E4 genotype, hyperlipidemia, resulting

in the accumulation of aggregated proteins such as amyloid-beta (A) in the

walls of arteries as cerebral amyloid angiopathy. Soluble antigens are eliminated

from the brain along the intramural periarterial drainage pathways, towards the

cervical lymph nodes. Arteries in the grey matter of the brain possess a layer of

leptomeninges as advenitita, whereas arteries in the white matter have two such

layers, with a potential perivascular space that becomes dilated when drainage of

fluid is impaired in the greymatter. Themotive force for efficient clearance of fluids

is provided by the contractions of smooth muscle cells and therapeutic strategies

to facilitate the clearance of fluid and prevent neurodegenerative diseases may be

based on adrenergic and cholinergic interventions.

Biography

Roxana Carare is a medically qualified Clinical Neuroanatomist

who has graduated in General Medicine in Bucharest Romania

in 1996 and completed her PhD in Experimental Neuropathol-

ogy in the Faculty of Medicine, University of Southampton, UK.

She has a rich educational portfolio and leads research into the

lymphatic drainage pathways of the brain. She has published

more than 50 papers in peer- reviewed journals, 4 book chap-

ters and has been serving as a Board Member on international

organisations and an Editorial Board Member of repute for sev-

eral journals.

Failure of perivascular drainage and

pathogenesis of neurodegenerative

diseases

Roxana O Carare

University of Southampton, UK

Roxana O Carare, J Neurol Neurosci 2018, Volume: 9

DOI: 10.21767/2171-6625-C1-007