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Volume 4 Nano Research & Applications
ISSN: 2471-9838
Page 56
August 16-18, 2018 | Dublin, Ireland
&
JOINT EVENT
12th Edition of International Conference on
Nanopharmaceutics and Advanced Drug Delivery
25th Nano Congress for Future Advancements
Nano Congress 2018
&
Nano Drug Delivery 2018
August 16-18, 2018
Pre-formulation of Nanostructured Lipid Carriers (NLC) for drug delivery: Excipient-excipient interaction
NLCs are composed by at least one solid lipid, one oil, surfactant and water. Previous works used regular purified oils and
focused mostly on dosage form optimization; however these approaches present contaminants that can mask or mislead
interactions, whereas optimization designs allows few excipients to be tested. Therefore, our goal was to assess physicochemical
interactions due to super refined lipids and surfactants in NLCs loaded with lidocaine. Free drug analysis included: drug
solubility and partition coefficient, thermal profile of solid excipients. NLC was formulated according to nonregular design
of experiment (Hall 2, 2 levels of substance concentration, 8 excipient inputs and 1drug input). NLC outputs included
z-average, polydispersity index, zeta potential and entrapment efficiency. Z-average (ZA) presented unimodal distribution,
mean size (322±47) nm. The interaction between polysorbate-80 (PS), castor oil (CA) and cetyl palmitate (CP) affected ZA.
Polydispersity index (PDI) variated between 0.14 to 0.35, mean (0.23±0.05). The main factors that influenced PDI were PS, CP
and CA. Zeta potential (ZP) presented mean value (-46.2±4.4) mV. Surfactants influenced ZP values depending on the liquid
lipids. Entrapment efficiency was between 58% and 79%, mean (72±5)% and interaction among liquid lipids was crucial to
this output, such as cottonseed (CS) and capric/caprylic (CC) oils. Based on the responses, CA, CP, CC and PS were the most
interactive excipients; our innovative approach provided an extensive information base, broad excipient analysis, unpublished
interactions and relevant information for further formulation optimization.
Biography
Laura de Oliveira Nascimento has completed her PhD from University of São Paulo (USP), Brazil in 2011 with Doctoral internship at Boston University, USA, and Post-
doctoral studies in USP. She is a Professor at State University of Campinas, Brazil. Her research group is focused on nanotechnology and freeze dried pharmaceutical
dosage forms.
Laura Oliveira Nascimento
State University of Campinas, Brazil
Laura Oliveira Nascimento, Nano Res Appl 2018, Volume 4
DOI: 10.21767/2471-9838-C3-014