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Volume 4 Nano Research & Applications
ISSN: 2471-9838
Page 48
JOINT EVENT
August 16-18, 2018 | Dublin, Ireland
&
12th Edition of International Conference on
Nanopharmaceutics and Advanced Drug Delivery
25th Nano Congress for Future Advancements
Nano Congress 2018
&
Nano Drug Delivery 2018
August 16-18, 2018
Nano-amorphous Abiraterone acetate formulation with improved bioavailability and eliminated food
effect
Tamás Solymosi, Réka Angi, Orsolya Basa Dénes, Tamás Jordán and Hristos Glavinas
NanGenex Inc., Hungary
Abiraterone acetate (AA) is a poorly water soluble drug molecule indicated for metastatic castration resistant prostate
cancer. The drug product Zytiga possesses the highest food effect of all marketed drugs. Despite of the extremely poor
absorption of AA in fasted conditions, Zytiga is to be taken strictly without food. We have developed a nano-amorphous
abiraterone acetate formulation prepared by controlled precipitation followed by lyophilization. The formulation exhibited
higher apparent solubility and passive permeability when compared to either the crystalline AA or Zytiga. DLS (Dynamic
Light Scattering) measurements and filtration experiments yielded particle size in the 100-200 nanometer range when the
solid formula was reconstituted in water. The active ingredient in the formulation was amorphous by XRD (X-ray Powder
Diffraction). Beagle dog studies showed 10-fold increase in exposure from the novel formulation when compared to the
marketed drug. Also, the marked food effect seen with Zytiga was not observed for the nano-amorphous AA. A first-in-human
clinical trial was conducted with a lyophilized powder-in bottle formulation in healthy male volunteers. The active ingredient
was rapidly absorbed in both the fasted and the fed states. Based on the PK (Pharmacokinetics) analysis a 250 mg dose of the
novel formulation is predicted to give the same exposure as 1000 mg Zytiga in the fasted state. As in preclinical studies, the
significant positive food effect was eliminated. Moreover, variability of exposure was reduced when compared to Zytiga. In
conclusion we have developed a novel nano-amorphous AA formulation that significantly outperformed the marketed .
Recent Publications
1. Solymosi T et al. (2017) Novel formulation of abiraterone acetate might allow significant dose reduction and eliminates
substantial positive food effect. Cancer Chemotherapy and Pharmacology. 80(4):723-728.
2. Solymosi T et al. (2017) Development of an abiraterone acetate formulation with improved oral bioavailability guided
by absorption modeling based on in vitro dissolution and permeability measurements. International Journal of
Pharmaceutics. 532(1):427-434.
3. Goldwater R et al. (2017) Comparison of a novel formulation of abiraterone acetate vs. the originator formulation in
healthy male subjects: Two randomized, open-label, crossover studies. Clinical Pharmacokinetics.
4. Papangelou A et al. (2017) the effect of food on the absorption of abiraterone acetate from a fine particle dosage form:
a randomized crossover trial in healthy volunteers. Oncology and Therapy.
5. Chi K N et al. (2015) food effects on abiraterone pharmacokinetics in healthy subjects and patients with metastatic
castration-resistant prostate cancer. The Journal of Clinical Pharmacology. 55(12):1406-1414.
Biography
Tamás Solymosi holds an MSc Degree in Chemical Engineering and currently working on his PhD thesis about the formulation of abiraterone acetate. He has been
working at NanGenex, Budapest, Hungary for the past 9 years, gaining experience in the formulation of poorly water soluble active ingredients. He is interested in
the physicochemical background of nanoformulation and bioavailability increasing technologies.
Tamás Solymosi et al., Nano Res Appl 2018, Volume 4
DOI: 10.21767/2471-9838-C3-014