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Volume 4 Nano Research & Applications
ISSN: 2471-9838
Page 49
JOINT EVENT
August 16-18, 2018 | Dublin, Ireland
&
12th Edition of International Conference on
Nanopharmaceutics and Advanced Drug Delivery
25th Nano Congress for Future Advancements
Nano Congress 2018
&
Nano Drug Delivery 2018
August 16-18, 2018
Controlled release of bovine serum albumin from surfactant modified alginate beads
Nilay Kahya and F Bedia Erim
Istanbul Technical University, Turkey
Alginate is a biopolymer which is used in several biomedical applications by means of its favorable properties, such as
biodegradability, biocompatibility and non-toxicity. In the present study, the availability of alginate gel to encapsulate and
release a protein type drug was investigated. The use of alginate has been reported before for the controlled release of bovine
serum albumin (BSA), however favorable controlled release behavior was only achieved by the help of clay incorporation to
alginate beads. Recently, it was reported that incorporation of anionic surfactant, sodium dodecyl sulfate (SDS) into alginate
increases the Young’s modulus of the alginate beads. Moreover, SDS and bovine serum albumin interaction via complexation
mechanism was reported. In the light of the last two works, SDS was incorporated into alginate beads to enhance protein-
loading efficiency of hydrogel and to prevent the burst release of protein drug. Bovine serum albumin (BSA) was used as model
protein drug. It was found that SDS modified calcium alginate beads encapsulated almost the initial amount of loaded drug. The
protein release experiments were done in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF). Results of release
experiments showed that SDS modified alginate beads showed controlled and time efficient drug release. Characterization
of the beads was performed by Scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), and
swelling experiments, respectively.
Recent Publications
1. Kaygusuz H and Erim F B (2013) Alginate/BSA/montmorillonite composites with enhanced protein entrapment and
controlled release efficiency. Reactive and Functional Polymers. 73(11):1420-1425.
2. Kaygusuz H et al. (2016) Surfactant and metal ion effects on the mechanical properties of alginate hydrogels.
International Journal of Biological Macromolecules. 92:220-224.
3. Matei I et al. (2014) Cationic spin probe reporting on thermal denaturation and complexation−decomplexation of BSA
with SDS: potential applications in protein purification processes. Journal of Physical Chemistry B 118(38):11238-
11252.
Biography
Nilay Kahya completed her MSc Degree in Chemistry at ITU Graduate School of Science Engineering and Technology in 2016. She is currently a PhD candidate
working under the guidance of Professor F Bedia Erim Berker. Her research field of interest are mainly related to the applications of biopolymers in drug delivery
systems and adsorption fields. She has four publications in Science Citation Index Expanded journals by March 2018.
Nilay Kahya et al., Nano Res Appl 2018, Volume 4
DOI: 10.21767/2471-9838-C3-014