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Volume 4
Nano Research & Applications
ISSN: 2471-9838
Page 41
Notes:
August 16-18, 2018 | Dublin, Ireland
&
JOINT EVENT
12
th
Edition of International Conference on
Nanopharmaceutics and Advanced Drug Delivery
25
th
Nano Congress for Future Advancements
Nano Congress 2018
&
Nano Drug Delivery 2018
August 16-18, 2018
Smart biomimetic nanoparticles: A new platform for nanomedicine
T
he ever increasing need of more effective and targeted therapies for the treatment of cancer and various degenerative
pathologies is pushingmaterial scientists to develop new solutions associating enhanced safety with smart functionality, also
permitting the establishment of personalized therapeutic approaches. In this respect, the development and use of nanoparticles
is today limited by several factors among which: i) low biodegradability and biocompatibility; ii) toxic by-products; iii)
uncontrolled drug release into the bloodstream; iv) limited cell-target specificity and v) low efficiency in crossing biological
barriers. In this respect a novel apatite based nanoparticle(NPs) have attracted the attention of scientific community for
biological and medical purposes as promising materials in drug or gene delivery, DNA/biomolecules separation, hypothermal
treatment of tumours, contrast agents for imaging, and recently in tissue engineering and theranostic applications. Recently,
novel biomimetic, fully biodegradable and cytocompatible NPs fabricated by doping hydroxyapatite (HA) with Fe ions (FeHA),
avoiding the presence of magnetic secondary phases and coating, were developed and biologically tested as new drug delivery
systems. The wide possibility of surface functionalization of apatitic nanoparticles significantly extends the potential to develop
smart drug carriers with active or passive ability to cross physiological barriers and to reach relevant organs such as the brain,
the lung or the heart.
Biography
Monica Montesi has obtained her PhD in Cellular and Molecular Biology at the University of Bologna and she has 12 years of expertise in cellular and molecular biology
associated to material science for nanotechnology, tissue engineering research and regenerative medicine. She is a scientific coordinator of NanoBioMagnetism Labora-
tory. She is an author of 40 papers published in international journals, several book chapters and more than 30 congress communications. She has been serving as an
Editorial Board Member of international
Journal of Bone and Mineral Metabolism
and Guest Editor of
International Journal of Molecular Sciences
.
[email protected]Monica Montesi
National Research Council of Italy, Italy
Monica Montesi, Nano Res Appl 2018, Volume 4
DOI: 10.21767/2471-9838-C3-014