nano-congress-nano-drug-delivery-2018-tracks

18 / 33

Volume 4 Nano Research & Applications
ISSN: 2471-9838
Page 39
Notes:
August 16-18, 2018 | Dublin, Ireland
&
JOINT EVENT
12th Edition of International Conference on
Nanopharmaceutics and Advanced Drug Delivery
25th Nano Congress for Future Advancements
Nano Congress 2018
&
Nano Drug Delivery 2018
August 16-18, 2018
Attractive advanced cell therapy by using bioresorbable magnetic nanoparticles
C ell therapy is one of the most exciting and promising areas for disease treatment and regenerative medicine. However
the success rate of cell-based therapies, despite their great potential, is limited mainly due the ineffective delivery and
retention of therapeutic cells in the specific organ. Magnetic targeting has emerged as a method to overcome these limitations.
So far these attempts have used superparamagnetic iron oxide nanoparticles (SPIONs), only clinically approved metal
oxide nanoparticles. Nevertheless the exposure to SPIONs has always been associated with significant toxic effects such as
inflammation, apoptosis and generation of ROS. Our group, by doping hydroxyapatite (HA), the mineral component of bone,
with Fe2+/Fe3+ ions, had obtained novel biocompatible and fully bioresorbable superparamagnetic nanoparticles (FeHA). This
work demonstrates the opportunity of FeHA in mesenchymal stem cells (MSCs) labeling. MSCs easily internalized the FeHA,
and they became magnetic enough to be guided and retained to specific site by a magnet. Magnetic MSCs maintained their
morphology and cell viability was not negatively affected. Due the well-known osteoinductive feature of HA, magnetic MSCs
overexpress osteogenic genes. We are also investigating the possibility to combine these above-mentioned results with the
contrast ability of FeHA for a real time imaging of the magnetic MSCs in vivo by magnetic resonance imaging. In conclusion,
due to the intrinsic magnetic properties of FeHA, its fast degradation and very low iron content compared to SPIONs, this
approach could be simply transferred to different cell types obtaining an attractive advanced approach for several regenerative
medicine applications.
Biography
Silvia Panseri is a Biologist and has completed her PhD in 2009 at the University of Milan, Italy. Her research activity is mainly focus on nano and regenerative medicine.
She has great expertise in cell-biomaterial interactions at the nanoscale, in magnetic cell guiding and 3D cell culture in bioreactor with several scaffolds. She is an author
of more than 50 papers published in international peer-reviewed journals, 12 book chapters, co-inventor of two patents and H-index=19. She has been serving as a Guest
Editor in International Journal of Molecular Sciences and Frontiers in Bioengineering and Biotechnology.
Silvia Panseri
National Research Council of Italy, Italy
Silvia Panseri, Nano Res Appl 2018, Volume 4
DOI: 10.21767/2471-9838-C3-014