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Volume 4

Nano Research & Applications

ISSN: 2471-9838

Page 39

Notes:

August 16-18, 2018 | Dublin, Ireland

&

JOINT EVENT

12

th

Edition of International Conference on

Nanopharmaceutics and Advanced Drug Delivery

25

th

Nano Congress for Future Advancements

Nano Congress 2018

&

Nano Drug Delivery 2018

August 16-18, 2018

Attractive advanced cell therapy by using bioresorbable magnetic nanoparticles

C

ell therapy is one of the most exciting and promising areas for disease treatment and regenerative medicine. However

the success rate of cell-based therapies, despite their great potential, is limited mainly due the ineffective delivery and

retention of therapeutic cells in the specific organ. Magnetic targeting has emerged as a method to overcome these limitations.

So far these attempts have used superparamagnetic iron oxide nanoparticles (SPIONs), only clinically approved metal

oxide nanoparticles. Nevertheless the exposure to SPIONs has always been associated with significant toxic effects such as

inflammation, apoptosis and generation of ROS. Our group, by doping hydroxyapatite (HA), the mineral component of bone,

with Fe

2+

/Fe

3+

ions, had obtained novel biocompatible and fully bioresorbable superparamagnetic nanoparticles (FeHA). This

work demonstrates the opportunity of FeHA in mesenchymal stem cells (MSCs) labeling. MSCs easily internalized the FeHA,

and they became magnetic enough to be guided and retained to specific site by a magnet. Magnetic MSCs maintained their

morphology and cell viability was not negatively affected. Due the well-known osteoinductive feature of HA, magnetic MSCs

overexpress osteogenic genes. We are also investigating the possibility to combine these above-mentioned results with the

contrast ability of FeHA for a real time imaging of the magnetic MSCs

in vivo

by magnetic resonance imaging. In conclusion,

due to the intrinsic magnetic properties of FeHA, its fast degradation and very low iron content compared to SPIONs, this

approach could be simply transferred to different cell types obtaining an attractive advanced approach for several regenerative

medicine applications.

Biography

Silvia Panseri is a Biologist and has completed her PhD in 2009 at the University of Milan, Italy. Her research activity is mainly focus on nano and regenerative medicine.

She has great expertise in cell-biomaterial interactions at the nanoscale, in magnetic cell guiding and 3D cell culture in bioreactor with several scaffolds. She is an author

of more than 50 papers published in international peer-reviewed journals, 12 book chapters, co-inventor of two patents and H-index=19. She has been serving as a Guest

Editor in

International Journal of Molecular Sciences

and Frontiers in

Bioengineering and Biotechnology

.

[email protected]

Silvia Panseri

National Research Council of Italy, Italy

Silvia Panseri, Nano Res Appl 2018, Volume 4

DOI: 10.21767/2471-9838-C3-014