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Microbiology & Virology 2018
J u n e 2 1 - 2 2 , 2 0 1 8
P a r i s , F r a n c e
Page 33
Archives of Clinical Microbiology
ISSN 1989-8436
E u r o S c i C o n C o n f e r e n c e o n
Microbiology &
Virology
F
ew viruses have properties that permit them to inflict lethal effects or even
cause overt clinical disease in all of the hosts they infect. Instead, a broad
range of consequences is the usual pattern of events observed. These depend
on variables in both the virus and the host. A variable which has received
limited study is the influence of host metabolism. We shall show that inhibiting
glucose utilization during infection with herpes simplex virus (HSV) has
dramatic effects on viral pathogenesis. Inhibition at the time when herpetic
lesions occur in the infected cornea results in decreased disease for reasons
explained by the differential effects on T cells involved in inflammation.
However, inhibiting glucose metabolism from the onset of infection resulted
in a syndrome that models human herpes encephalitis with the majority of
animals succumbing to lethal encephalitis. This outcome will be explained
by the effects of glucose deprivation on innate immunity at the infection site
and adaptive CD8 T cell mediated immune changes in the local nerve ganglion.
Together these effects result in more viral replication and a failure to maintain
viral latency. We shall also describe the effects of manipulating fatty acid
metabolism on the stability of herpesvirus latency in the peripheral nervous
system. Our results will be discussed in terms of the relevance of metabolic
changes that can influence the outcome of other viral infections.
Biography
Barry T. Rouse graduated with a veterinary degree from
Bristol, Englane in 1965. After a brief stint as a practitioner, he
undertook graduate studies in Canada obtaining MSc and PhD
degrees. He then had a two year postdoctoarl experience at the
Walter and Eliza Hall Institute of medical research, Melbourne
Australia, prior to returning to Canada as an Assistant professor
where he established his independant laboratory. In I977 he
moved to Tennesses where he is currently the Lindsay Young
Distinguished Professor. Doctor Rouse considers himself a
viral immunologist and has written >400 articles with citations
of >22000 and a H index of 81. He has trained almost 80
trainees and stays in touch with the majority of them. Thanks
to his trainees he has won numerous awards for his research
accomplishments.
btr@utk.eduHow metabolic events may influence the pathogenesis of a virus
infection
Barry T. Rouse, Naveen Rajasagi and Karthik Varanasi
University of Tennessee, USA
Barry T. Rouse et al., Arch Clin Microbiol 2018 Voulume: 9
DOI: 10.4172/1989-8436-C3-011