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Volume 2, Issue 1
Neurosurg
ISSN: 2471-9633
Global Stroke 2017
July 05-06, 2017
Neurodegenerative Disorders and Stroke
July 05-06, 2017 Frankfurt, Germany
4
th
International Conference on
Md Mahbubur Rahman et al., Neurosurg 2017, 2:1
DOI: 10.21767/2471-9633-C1-003
Rice bran oil improves behavioral disorder in AlCl3 induced dementia
Md Mahbubur Rahman, Waeza Tahsin Chowdhury, Md Abdullah Potol, Saba Reza, Mahmuda Arefin Mumu, Mahabub Alam, Abdirahman Adam Ibrahim Nur,
Afrida Fyroz, Sharmin Sultana, Asha Akter
and
Monjur Murshid
North South University, Bangladesh
T
he prevalence of Alzheimer’s diseases is quite high in developed countries as well as in low income countries. Dementia is one
of the major phenotypes observed in Alzheimer’s disease. The treatment options for Alzheimer’s disease and dementia are not
devoid of flaws and drugs with optimum effects are still to be discovered. Natural products on the other hand are a good source of
lead compounds. Here, we investigated the effect of rice bran oil (RBO) on a mouse model of dementia. Eight to ten weeks old Swiss
albino mice were injected with low dose AlCl
3
for two weeks to induce mild dementia. Morris water maze (MWM) and radial arm
maze (RAM) test were performed to evaluate the memory function. We also measured oxidative stress in brain. In the RAM test,
the number of total error increased substantially after treatment with AlCl
3
. However, when we treat mice with RBO, a significant
reduction was observed. In MWM test, latency to the target increases significantly after AlCl
3
injection which was reversed upon
treatment with RBO. In open field test, we noticed that AlCl
3
treated mice travelled longer distance than the one with RBO. Lipid
peroxidation was significantly higher in the hippocampus of disease group which was reduced in RBO group. Oxidative stress marker
NO was also significantly reduced with RBO treatment compared to the disease group. Therefore, we conclude that rice bran oil
improves spatial memory function associated with reduced oxidative stress and lipid peroxidation.
Biography
Md Mahbubur Rahman is a teaching professional with progressive experience in research. He has demonstrated high level of ingenuity in research in the field of
Neuropharmacology. In 2013, Dr. Rahman received his doctoral degree from the Heidelberg University, Germany. He is an expert in animal model of stroke. He
completed MS in Pharmaceutical Sciences and Bachelor of Pharmacy from Jahangirnagar University, Dhaka in 2008 and 2006 respectively. Currently, he is working
as an Assistant Professor and focusing his research on developing an animal model in an attempt to figure out the impact of food habits on neurodegenerative
disorders.
rahman.mahbubur@northsouth.edu