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Volume 2, Issue 1
Neurosurg
ISSN: 2471-9633
Global Stroke 2017
July 05-06, 2017
Neurodegenerative Disorders and Stroke
July 05-06, 2017 Frankfurt, Germany
4
th
International Conference on
Neurosurg 2017, 2:1
DOI: 10.21767/2471-9633-C1-003
No-ing” Primary Progressive Aphasia: Evolution of a Concept
Rhonna Shatz
University of Cincinnati, USA
T
his lecture is designed to provide an updated context for the classifications of primary progressive aphasias (PPA) and an expanded
clinical rubric for differential diagnosis. Initially the neurodegenerative aphasias were defined based on the lesion localization
classifications of cerebrovascular disease. However, the recognition that brain function is organized into three main networks--the
default network, the frontal-executive network, and the salience network—allowed an expansion of the understanding of language
organization and the ability to define the PPA according to network functions. Currently the classification system attempts to relate
phenotypic presentations of the 3 differentiated PPAs according to regions of maximal atrophy or metabolic dysfunction focused
on language alone. However, by viewing the concepts of brain network organziation on an evolutionary background of language
development, there is a broader set of features that may more closely identify the phenotype and neuropathology of each syndrome.
This lecture will present the concepts of PPA as part of an understanding of how language fits overall into the brain’s overarching
goal of enhancing survival, present a clinical rubric for defining the concept of fluent versus nonfluent PPA, integration of Tempini’s
classification system into an expanded evolutionary framework, and then discuss each syndrome individually, including videotaped
examples of each subtype.
shatzra@ucmail.uc.edu