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Volume 2, Issue 1
Neurosurg
ISSN: 2471-9633
Global Stroke 2017
July 05-06, 2017
Neurodegenerative Disorders and Stroke
July 05-06, 2017 Frankfurt, Germany
4
th
International Conference on
Md Mahbubur Rahman et al., Neurosurg 2017, 2:1
DOI: 10.21767/2471-9633-C1-003
Coenzyme Q10 Ameliorates Hyperlipidemia Induced Brain Oxidative Stress and Inflammation
Md Mahbubur Rahman, Md Abdullah Potol , Sourov Roy, Saiky Jahan Elona, Abir Hossain, Rifat Sultana, Mahabub Alam, Zaki Forhad Habib, Rasiqh Wadud
A F M Towheedur Rahman
North South University, Bangladesh
O
xidative stress is a common deneomentor in many diseases processes including hyperlipidemia. Persistent oxidative stress may
result in inflammation which eventully lead to other diseses including neurodegenation. Thus optimum tritration of oxidative
stress is essential for proper brain function. Coenzyme Q10 is a powerfull antioxidant and has been reported as a scanvenger of
oxidative stress. Hyperlipidemia on the other hand aggravate the outcome in neurodegenerative disorders by enhancing oxidative
stress. Therefore, in our current study, we evaluated the effect of coenzyme Q10 in a setting of hyperlipidemia.Hyperlipidemia
was induced by a single intraperitoneal injection of Tyloxapol into eight weeks old mice. Twenty four hours after the injection,
mice were sacrificed and plasma were collected for the measurement of biochemical parameters. The treatment group received
Coenzyme Q10 at a dose of 150 mg /kg BW. We noticed that plasma triglyceride and Cholesterol level was significantly higher in
mice with hyperlipidemia compared to the control group. Coenzyme Q10 treatment reduced plasma cholesterol and triglyceride level
significantly which was comparable to the standard treatment Rosuvastatin. Lipid peroxidation in plasma was significantly higher
in mice with hyperlipidemia which was normalized upon coenzyme Q10 treatment. However the lipid peroxidation in brain was
unachaned in mice of different groups. We noticed significantly higher concentration of NO, marker of oxidative stress, in brain and
plasma. Coenzyme Q10 treatment reduced the level of NO in brain and plasma significantly.Coenzyme Q10 reduces hyperlipidemia
induced oxidative stresss and inflammation in brain and plasma most likely by enhancing antioxidative defense mechanism.
Biography
Md Mahbubur Rahman is a teaching professional with progressive experience in research. He has demonstrated high level of ingenuity in research in the field of
Neuropharmacology. In 2013, Dr. Rahman received his doctoral degree from the Heidelberg University, Germany. He is an expert in animal model of stroke. He
completed MS in Pharmaceutical Sciences and Bachelor of Pharmacy from Jahangirnagar University, Dhaka in 2008 and 2006 respectively. Currently, he is working
as an Assistant Professor and focusing his research on developing an animal model in an attempt to figure out the impact of food habits on neurodegenerative
disorders.
rahman.mahbubur@northsouth.edu