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Notes:
Volume 4
Journal of Infectious Diseases and Treatment
ISSN: 2472-1093
Page 17
Euro Infectious Diseases 2018 &
Histopathology 2018
September 27-29, 2018
&
JOINT EVENT
September 27-29, 2018 Rome, Italy
5
th
International Conference on
Histopathology & Cytopathology
10
th
Euro-Global Conference on
Infectious Diseases
Fernanda de Freitas Anibal et al., J Infec Dis Treat 2018, Volume 4
DOI: 10.21767/2472-1093-C1-002
Hepatic fibrosis in schistosomiasis, a new treatment
Fernanda de Freitas Anibal
1
, Karina A. Feitosa
1
, Ricardo de O. Correia
1
, Vanderlei Rodrigues
2
, Ana Afonso
1
, Karina N. Z. P. Rossi
1
and
Lucimar R. S Avó
1
1
Federal University of São Carlos, Brazil
2
Faculty of Medicine of Ribeirão Preto, Brazil
S
chistosomiasis is an important parasitic disease caused by Schistosoma mansoni, an intravascular trematode. Praziquantel
(PZQ) is the only treatment for this. Thus, studies on new antischistosomal compounds are fundamental for disease
control. In our model, Mentha piperita L. compounds – menthol and menthone (MM) – in association with acetylsalicylic
acid (ASA) is demonstrated in the regulation of hepatic fibrosis caused by schistosomiasis granulomas. Six different groups
of ice were infected with 80 cercariae (groups: infected and untreated, infected and MM treatment; infected and treatment
MM with ASA, all treated during 14 daily after 35 day pos infection; and infected treated with Praziquantel (single dose).
Parasitological, cytological and histological analyses were performed. The number of eosinophils in the peritoneal cavity lavage
(LPC) significantly reduced in all treated groups. Groups treated with 30 mg/kg of MM presented a 62.80% reduction and
groups treated with 50 mg/kg of MM + ASA presented a 64.21% in the number of eggs. In the liver´s histological analysis we
observed that all MM treated groups expressed a unique cytological profile, with diffused cells around the granuloma. In the
experimental group treated with 50 mg/kg of MM + ASA, it was possible to observe the formation of type III collagen fibers,
a typical wound healing characteristic. Our data strongly suggests that both the hepatic fibrosis and the inflammatory process
were regulated through the schistosomiasis granulomatous process after treatment with MM with ASA.
Biography
Fernanda de Freitas Anibal is a Associate Professor in Federal University of São Carlos and Principal Investigator at Laboratory of Inflammation and Infectious
Diseases, Brazil. Currently, they are working with plants and enzymes and their effects againts schistosomiasis and leishmaniasis, about the treatment of infectious
diseases. Their group studies effects of plants and their isolated fractions in order to evaluate the anti-parasitic and anti-inflammatory effects for infectious disease
control. She has published more than 46 papers in scientific journals.
feranibal@yahoo.com