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Volume 4
Journal of Infectious Diseases and Treatment
ISSN: 2472-1093
Page 31
Euro Infectious Diseases 2018 &
Histopathology 2018
September 27-29, 2018
&
JOINT EVENT
September 27-29, 2018 Rome, Italy
5
th
International Conference on
Histopathology & Cytopathology
10
th
Euro-Global Conference on
Infectious Diseases
Molecular testing in histologically benign spindle cell proliferations
Atif A Ahmed
Children’s Mercy Hospital, USA
H
istologically low grade spindle cell tumors in children are mostly benign and easily cured. Infrequency, such tumors can
be infiltrative, commonly recur and are difficult to classify and surgically excise. Molecular tests including next generation
seuencing have greatly faciltated the diagnosis and the treatment of highly malignant tumors but are rarely ultized in the
management of undifferentiated low grade spindle proliferations. In the last three years, we have encountered two unusual cases
of histologicaly benign infiltrative spindle cell proliferation in children that were studied by whole exome sequencing. The first
case was that of a 20-cm abdominal mass that extended to the pelvis in a young child. The histology revealed bland spindle cell
proliferation that infiltrated skeletal muscles and adipose tissue. The CD34-positive cells did not show any immunoreactivity to
any other marker. Whole exome sequencing revealed
NF1
gene mutation suggesting origin from peripheral nerve sheath. The
second case was that of an infant who had right a nasal tumor involving the maxillary sinus and turbinates and extending to the
skull base. The recurrent tumor shows focal early osteoid formation and was negative for
ALK, CTNNB1
and
GNAS
mutations.
Exome sequencing revealed RET Glu511Lys variant. In both cases, potential benefit by several tyrosine kinase inhibitors was
revealed. In conclusion, molecular sequencing for actionable mutations is valuable in the management of low grade infiltrative
spindle cell lesions in children.
Biography
Atif A Ahmed is Professor and Director of Anatomic Pathology Division at the Department of Pathology of Children's Mercy Hospitals, Kansas City, USA. He has
graduated from University of Khartoum in 1988, completed residency and fellowship training in Pathology and is certified by the American Board of Pathology. He
has published more than 50 peer-reviewed articles as well as several book chapters; and is a book editor of
"Anatomic and Clinical Pathology Board Review"
and
"Gastrointestinal Stromal Tumors in Adults and Children".
He is on the editorial board of several journals.
aahmed@cmh.eduAtif A Ahmed, J Infec Dis Treat 2018, Volume 4
DOI: 10.21767/2472-1093-C1-002