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Volume 3, Issue 2 (Suppl) Trends in Green chem
ISSN: 2471-9889 Environmental & Green Chemistry 2017
July 24-26, 2017
Page 69
5 th International Conference on
6 th International Conference on
July 24-26, 2017 Rome, Italy
Environmental Chemistry and Engineering
Green Chemistry and Technology
&
Ultrasound and microwaves assisted synthesis of molecules with antiquorum sensing activity
Alicia Reyes-Arellano, Jenifer Torres-Jaramillo and Delfino J Vera-Mercado
National Polytechnic Institute, Mexico
Statement of the Problem: It is necessary to synthesize molecules that can function as biososteres1 of acyl homoserine lactones2
(AHL) or bioisósteres of tirosol,3 which can be evaluated on Gram-negative bacteria or Candida albicans respectively. On the other
hand it is indispensable that the synthesis is carried out considering energy efficiency, operational simplicity and good yield in short
times. By the above mentioned, molecules were designed for this purpose and planted some chemical synthesis procedures.
Findings: Compounds 1 were synthesized in two steps, from p-hidroxy benzaldehyde,4 one of them was carried out by sonication.
Compounds 2 were totally synthesized by sonication, based on a report of literature5; global isolated yield 85-95%. Synthesis of
compounds 3 and 4 involves a cyclization, it was carried out by MW or ultrasound. Good yields were obtained when the raw material
contain long chains. Excellent yields were achieved when the raw material had short chains. The ultrasound has the advantage the
time is minimum compared with MW or conventional heating. Compounds 3 were prepared from p-amino toluene and compound
4 from p-hydroxibenzaldehyde. It is important to mention that alkylation of p-hydroxibenzaldehyde demands 18h of heating, while
using MW the reaction requires only 4h and 2h with ultrasound.
Conclusion & Significance: Diols, alcohols and imidazolines were prepared using a very simple protocols using MWor ultrasound in
good to excellent yields. The synthesized compounds are currently evaluated as antiquorum sensing molecules in Serratia marcescens
and Candida albicans, in fact some of them present activity as antiquorum sensing compounds.
Biography
Alicia Reyes-Arellano has her expertise in design and synthesize of compounds with pharmacological activity and passion in improving the synthetic procedures
according the green chemistry. Her fields are organic chemistry, medicinal chemistry and nanostructures synthesis. She has interest in teaching and improved the
plans and curricula in her Institution. She is also interested on HPLC-MS studies
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Alicia Reyes-Arellano et al., Trends in Green chem, 3:2
DOI: 10.21767/2471-9889-C1-002