endocrinology-2018-scientifictracks

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Endocrinology 2018 Journal of Clinical and Molecular Endocrinology
ISSN: 2572-5432 Page 24
August 09-10, 2018
Madrid, Spain
11th International Conference on
Endocrinology and
Diabetology
Introduction: This study was conducted in Endocrine and
Diabetes Clinic (Cairo University) from 2016-2017 to evaluate
endothelial function using flow mediated vasodilatation (FMD)
of brachial arteries in subclinical hypothyroidism (SHT) to
provide a possible evidence for treating all patients with SHT.
Patients &Methods: The study included 48womenwith primary
hypothyroidism and 9 women as a control group. Hypothyroid
patients were divided to: Group I (overt hypothyroidism:
OHT) (n=24): elevated serum TSH, low FT3 & FT4 and were
subdivided into: Group IA: (n=6) on L-thyroxine with controlled
hypothyroidism: TSH in the laboratory reference range (0.4-
4.1 µIU/ml). Group IB: (n=18), 7 were naïve for L-thyroxine and
11 on L-thyroxine with uncontrolled hypothyroidism (TSH>4.1
µIU/ml). Group II (SHT) (n=24): elevated serum TSH, normal
FT3 & FT4, n=24) were not receiving L thyroxine subdivided
into: Group IIA: (n=10): TSH (4.1-10 µIU/ml). Group IIB: (n=14)
TSH (>10 µIU/ml).
Results:FMDwassignificantly lower in thedifferent hypothyroid
subgroups than control group and was comparable among the
4 hypothyroid subgroups with no correlation with serum TSH
(Right: 16.19±12%, 9.12±13.23%, 14.5±24.7%, 11.3±8.5%,
21.87±2.78% in groups IA, IB, IIA, IIB, control respectively
(P<0.019). Left: 12.04%±9.49%, 12.64±14.53%, 11.85±14%,
9.56±6.75%, 21.83±5.18% in groups IA, IB, IIA, IIB, control
respectively (P<0.002)).
Conclusions: Endothelial dysfunction is present in OHT and
SHT regardless the level of TSH. The role of L-thyroxine in
improving endothelial function is not consistent.
Biography
Dr ElhamMohamed yousief , lecturer of internal medicine , diabetes and en-
docrinology at faculty of medicine , cairo university .I have master and PHD
degree for internal medicine , also master degree for diabetes , endocrinol-
ogy , clinical nutrition and metabolism. Five published research. No previous
award and presentation at any conference.
Evaluation of flow mediated vasodilatation of the
brachial artery as a marker of endothelial dysfunction in
hypothyroidism
Elham Mohammed Yousief, Olfat Gamil Shaker, Naglaa Mohamed, Amr El
Meligi and Ahmed Sobhy
Cairo University, Egypt
Elham Mohammed Yousief et al., J Clin Mol Endocrinol 2018, Volume 3
DOI: 10.21767/2572-5432-C2-005