endocrinology-2018-scientifictracks

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Endocrinology 2018 Journal of Clinical and Molecular Endocrinology
ISSN: 2572-5432 Page 21
August 09-10, 2018
Madrid, Spain
11th International Conference on
Endocrinology and
Diabetology
Background: The problems of development of cardiovascular
disorders alongside with implementation of androgen
replacement therapy with testosterone medications have been
discussed in the scientific literature for a long time. Some
authors noted in their patients a high packed cell volume
characteristic of hormone replacement therapy, as well as
dyslipidemia and progressive arterial hypertension, which
develop with the use of androgenic anabolic steroids. Of course
the risk of developing side effects such as hypertension after
use of various forms of prolonged testosterone (testosterone
enanthate etc.) compared with that of use of anabolic steroids
is not the same. In our study the main attention is paid to such
problem as arterial hypertension, which appears against the
background of the use of anabolic preparations with progestin
activity, characterized by absence of a carbon atom in the 19th
position when compared with testosterone.
Objectives: The objective of this work is to study the special
characteristics of the course of hypertension (the rate of
progression) in patients who used drugs with anabolic activity
that contact with receptors of progesterone compared with
other forms of testosterone medications.
Materials & Methods: The study involved 44 patients (men)
aged 21 to 40 years, including 23 people who, according
to medical history, used drugs with anabolic and progestin
activity for 1 month or more (observation group) and 21
people who used anabolic steroids without progestin activity
(comparison group). Inclusion criterion - the level of luteinizing
hormone (LH) <1.24 mIU/ml. Dosages of drugs in both groups
are comparable in terms of their anabolic activity. Clinical
examination included analysis of complaints (headaches,
sleep disorders, edema (shins, eyelids, fingers), cardialgia
etc., morphophysiological indices, measurement of blood
pressure, ambulatory blood pressure monitiring, measurement
of heart rate. Blood sampling for biochemical and hormonal
research was conducted in the time interval from 8.00 to 11.00
am on empty stomach. The biochemical study included: full
blood count (FBC), lipid profile, hepatic enzymes, creatinine,
glycohemoglobin. The hormonal examination provided for
the determination of total testosterone, estradiol, luteinizing
hormone, follicle-stimulating hormone, prolactin.
Results:Asa result of thestudy, itwas found that 51%of patients
took progestin-active drugs, 49% - without progestin activity.
Arterial hypertension was observed in 27 (61%) patients, with
the first degree of arterial hypertension observed in 20% of
patients, the second degree in 27%, and the third degree in
14%. Also, edema was observed in 18 (61%) patients and sleep
disorders was observed in 18 (61%) patients. A positive relation
was found between taking drugs with progestin activity and a
high (2-3) degree of arterial hypertension (Chi-square 29.5,
p-value<0.000002).
Discussion: The use of any drug leading to an increase in blood
pressure should be accompanied by a study of its effect on
the current cardiovascular pathology and the frequency of
its development. All these medicines should be considered
as additional factors of cardiovascular risk. As a result of
our study a positive correlation was obtained between the
medications with progestin anabolic effect and development
of arterial hypertension in the examined patients (Chi-square:
29.5, p<0.001).
Conclusions: The use of anabolic drugs with progestin activity
is associated with a risk of hypertension which, in combination
with high packed cell volume and dyslipidemia, increases the
risk of cardiovascular disease in this group of patients.
Biography
Dr. Pavel Popov graduated from Faculty of Medicine, Peoples’ Friendship Uni-
versity of Popov based in Moscow and practiced as an Endocrinol-
ogist with the Сity Clinical Hospital named after A.K. has
authored and co-authored publications in key medical journals and Interna-
tional conferences in the fields of diabetes, hormones, andrology, obesity and
cardiovascular risk assessment.
Arterial hypertension in patients taking anabolic steroids with
progestin activity
Pavel Popov and Irina Kurnikova
RUDN University, Russia
Pavel Popov et al., J Clin Mol Endocrinol 2018, Volume 3
DOI: 10.21767/2572-5432-C2-005