endocrinology-2018-scientifictracks

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Endocrinology 2018 Journal of Clinical and Molecular Endocrinology
ISSN: 2572-5432 Page 23
August 09-10, 2018
Madrid, Spain
11th International Conference on
Endocrinology and
Diabetology
Failure to maintain an adequate acetylation balance of
chromatin, transcription factors and enzymes by p300/
CBP is widely involved in human disease from cancer to
neurodegeneration. How physiological or pathological
conditions or metabolites alter the acetylation balance to
drive broad changes in cancer cell gene expression, imposing
epigeneticmarks has been elusive. Herewe show themolecular
mechanisms that underlie induction of p300 activity under
hyperglycaemia, which results in general chromatin opening
to allow high rates of proliferation in gastrointestinal cancer
cells. We show the mechanistic details in vitro to discuss new
molecular targets and then we compare human samples from
diabetic and non diabetic patients.
Biography
Custodia García Jiménez graduated in Biology from University of Murcia
and from Autonomous University of Barcelona (Madrid) as Doctor in Biol-
ogy. She studied (Predoctoral) at Harvard Medical School- Massachusetts
General Hospital, Boston (USA) and (Postdoc) at European Molecular Biol-
ogy Laboratory, Heidelberg, (Germany) and Murdoch Children’s Research
Institute, UK with national (Spanish Ministry of Science & Education ) and
international fellowships (Marie-Curie Fellowships-EC). In 2002, she joined
King Juan Carlos University (URJC) where she teaches Physiology and
leads her research focused on molecular links between diabetes and can-
cer. She has collaborations with several international (UK and Japan) and
national institutions and hospitals attached to URJC.
Hyperglycaemia increases p300 acetyl-transferase activity in
colon cancer cells
Custodia García Jiménez1, Ana Chocarro Calvo1, Jose Manuel García Martínez1,
María Gutiérrez Salmerón1, Maria Carmen Fiuza2 and Antonio De la Vieja3
1King Juan Carlos University, Alcorcon, Spain
2Alcorcon Foundation University Hospital, Spain
3Carlos III Health Institute, Spain
Custodia García Jiménez et al., J Clin Mol Endocrinol 2018, Volume 3
DOI: 10.21767/2572-5432-C2-005