Viruses including SARS-COV-2 that is the etiologic agent of the COVID-19 pandemic, spatiotemporally evolves or mutates to its variant with potentialities for adverse opportunistic infections via replications and transmissions or disseminations. The dissemination and transmission of the Delta variant is accelerating more than expected partly due to unvaccinated persons not treating the pandemic as seriously as necessary. The test and tracing service must be effected because a vast proportion of the population is unprotected. It is crucial to restrict movements. Vaccinated persons must socialize indoors in well-ventilated ambients, and avoid non-essential foreign travels. The evolution of the COVID-19/SARS-CoV-2 pandemic portends a well-nigh impossible termination of events. It is, therefore, imperative to focus on the cost and not merely the opportunity cost to control the never-ending SARS-CoV-2/COVID-19 pandemic. We need to make the public health system a priority with emphasis on cost sharing and cost saving for vaccines and other healthcare modalities to reach the poor and the vulnerable populations in developing countries and elsewhere for safety and protection of lives through enhanced substantial, restorative and sustainable financing, technical expertise and capacity building.