Acoustic Tweezing Cytometry Induces Rapid Initiation of Human Embryonic Stem Cell Differentiation and Accelerate Neural Tube Like Rosette Formation

Mechanical forces play critical roles in influencing human
embryonic stem cell (hESC) fate. However, it remains largely
uncharacterized how local mechanical forces influence hESC
behavior in vitro and the impact of dynamic mechanical forces
on neural induction of hESCs. Here, we used an ultrasound
(US) technique, acoustic tweezing cytometry (ATC), to apply
targeted cyclic subcellular forces to hESCs via integrin-bound
microbubbles (MBs).

Author(s): Tugba Topal

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