Journal of Organic & Inorganic Chemistry

Chemoselective synthesis of homo- and heterovalent glycocyclopeptides

EuroSciCon Conference on Chemistry 2018
February 19-20, 2018 Paris, France

Olivier Renaudet

University of Grenoble Alpes, France

Posters & Accepted Abstracts: J Org Inorg Chem

DOI: 10.21767/2472-1123-C1-003

Abstract

Synthetic glycoclusters and glycodendrimers have stimulated increasing interests over the past decade. Among the large variety of multivalent scaffolds reported so far, our group is focusing on cyclopeptide-based glycoconjugates for diverse biological applications. In this context, welldefined structures with various size, sugar density and combination have been prepared using either single or orthogonal chemoselective procedures (i.e. oxime ligation, Huisgen 1, 3-dipolar cycloaddition, thiol-ene coupling, thiolchloroacetyl coupling). Here, we will present the synthesis of several homo- and heterovalent glycocyclopeptides and their biological properties as nanomolar lectin ligands and antitumoral vaccines.` olivier.renaudet@univ-grenoble-alpes.fr