Formulation Design and In vitro-In vivo Evaluation of Moxifloxacin Ophthalmic Insert

Background: Moxifloxacin is a fluoroquinolone derivative extensively used for ocular infection.
Objective: The main objective of study is to design and evaluate ophthalmic insert of moxifloxacin that could be use for sustained delivery of drug in to eye.
Method: The moxifloxacin ophthalmic insert was prepared by solvent casting method. The chitosan, methyl cellulose and hydroxyl propyl methyl cellulose K4M were used as release rate controlling biodegradable polymers. The drug excipients compatibility study was carried out by Fourier Transform Infrared Spectroscopy (FTIR) and study suggesting no interaction between drug and polymers. The ocuserts were characterized for weight variation, thickness, surface pH, folding endurance, moisture absorption, moisture loss, drug content uniformity, in vitro drug release, drug release kinetic, stability, sterility testing and ocular toxicity study. The ophthalmic inserts were evaluated for in vivo drug release studies.
Results: The uniformity of the weights of the films suggested uniform distribution of the drug and polymer in all formulations. Use of higher concentration plasticizer was observed to cause brittleness in the medicated discs, but use of greater amount of plasticizer displayed little opaqueness and good folding endurance. The ocular irritation test did not show any signs of irritation, inflammation and abnormal discharge.
Conclusion: The result indicated that the ophthalmic insert, F3 containing methyl cellulose (400 mg) released 71.5 % of drug, in a constant manner following zero order kinetics with adequate stability and non-toxic to eye, suggesting Moxifloxacin eye ocusert would be used for safe management of ocular disease with lesser frequency of administration.

Author(s): Bhabani Shankar Nayak, Suresh Chandra Patnaik, Suprava Sethy, P. Ellaiah and Bikas Kumar Sarangi

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