A member of the cytochrome P450 mixed-function oxidase system, which is involved in the metabolism of xenobiotic in the body. The CYP2 subfamily is responsible for the majority of P450-mediated drug metabolism in humans. While CYP2E1 itself carries out a relatively low number of these reactions and related enzymes CYP1A2 and CYP3A4 are responsible for the breakdown of a large number of toxic environmental chemicals and carcinogens that enter the body, in addition to basic metabolic reactions such as fatty acid oxidations.
Related Journals: Journal of Drug Metabolism & Toxicology, Journal of Pharmacokinetics & Experimental Therapeutics,Journal of Pharmacogenomics & Pharmacoproteomics , Journal of Bioequivalence & Bioavailability, Journal of Clinical & Medical Genomics, Pharmacogenomics Journal.
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