Anesthetic Absorption: Regional Anesthetic

Systemic absorption of LA is determined by site of injection, dosage and volume, addition of vasoconstricting additives, and pharmacologic profile of LA. Blood levels after injection of LA are highest for intercostal blocks > caudal> epidural> brachial plexus> sciatic/femoral> subcutaneous. (See table below.) The more vascular the region the higher the blood levels after injection. The addition of vasoconstrictors, like epinephrine, will lower the potential systemic toxicity of LA. Recommendations on maximal doses of LAs commonly found in pharmacology texts are not directly applicable to the practice of regional anesthesia. Any recommendation on the maximal doses can be valid only in reference to a specific nerve block procedure.

 

High Impact List of Articles

 

Recommended Conferences

  • International Conference on Advanced Medicine
    July 10-11, 2017 bangkok Thailand
  • Global Meeting on Pharmaceutics & Drug Delivery Systems
    July 31-Aug 02, 2017 Melbourne Australia
  • 4th International Conference and Exhibition on Pain Medicine
    August 03-04, 2017 San Francisco USA
  • 5th International Conference and Exhibition on Pain Research and Management
    September 04-05, 2017 London UK
  • 2nd International Conference on Anesthesia and Analgesia
    September 07-08, 2017 London UK
Flyer image