Research and Reports on Toxicology is a peer reviewed, open access journal dedicated to publish well researched scientific information related to variety of toxic substances and their possible effects on the environment and the living organism within it.
The journal encompasses a wide spectrum of specialities within this field by including chemical, aquatic, occupational, and environmental toxicity. To this effect, the journal accommodate research on Dose response complexities, Computational toxicology, chemical toxicity, mechanisms of toxicity, xenobiotics, Occupational toxicology, Aquatic toxicology, Ecotoxicology, Environmental toxicology, Medical toxicology, Toxicity, Toxicogenomics, Forensic toxicology, Entomotoxicology, and Toxinology.
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The ingestion or application of a drug or other substance in quantities greater than are recommended or generally practiced. An overdose may result in a toxic state or death. Overdose of a substance vary depending on the drug or toxin exposure. The symptoms can often be divided into differing toxidromes. This can help one determine what class of drug or toxin is causing the difficulties. Symptoms of overdoses include slow breathing, heart rate and pulse.
Related Journals: International Journal of Drug Development and Research, Journal of Pharmacogenomics & Pharmacoproteomics, Journal of Pharmacovigilance, Journal of Drugs and Toxins, Journal of Chemical Biology & Therapeutics, American Journal of Therapeutics, Journal of Human Pharmacology and Drug Therapy
It is the accumulation of a chemical in or on an organism when the source of chemical is solely water. Bio concentration is a term that was created for use in the field of aquatic toxicology. It can also be defined as the process by which a chemical concentration in an aquatic organism exceeds that in water as a result of exposure to a waterborne chemical.
Related Journals: Journal of Environmental & Analytical Toxicology, Journal of Bioremediation & Biodegradation, Journal of Marine Science: Research & Development, Journal of Clinical Toxicology, Journal of Pollution Effects & Control, Environmental Toxicology and Pharmacology
Toxins that are poisonous or destructive to nerve tissue .Neurotoxins are an extensive class of exogenous chemical neurological insults that can adversely affect function in both developing and mature nervous tissue. The term can also be used to classify endogenous compounds, which, when abnormally contacted, can prove neurologically toxic. Though neurotoxins are often neurologically destructive, their ability to specifically target neural components is important in the study of nervous systems. Common examples of neurotoxins include lead, ethanol (drinking alcohol), manganese glutamate, nitric-oxide, botulinum toxin (e.g: Botox), tetanus toxin and tetrodotoxin
Related Journals: Neurochemistry & Neuropharmacology, Brain Disorders & Therapy, Journal of Pediatric Neurological Disorders, Journal of Neurological Disorders, Journal of Clinical & Experimental Pharmacology, Journal of Neuroinfectious Diseases, Neurotoxicology and Teratology, International Journal of Molecular Sciences
Idiosyncratic drug reaction denotes an aberrant or bizarre reaction or hypersensitivity to a substance, without connection to the pharmacology of the drug. It is what is known as a Type B reaction. They are usually unpredictable, might not be picked up by toxicological screening, not necessarily dose-related, incidence and morbidity low but mortality is high. Type B reactions are most commonly immunological (e.g. penicillin allergy).
Related Journals: Journal of Allergy & Therapy, Journal of Allergy and Inflammation,Journal of Infectious Diseases & Preventive Medicine, Journal of Immunobiology, Journal of Vasculitis, American Academy of Allergy, Asthma & Immunology,Journal of Allergy and Clinical Immunology
Disturbances in the normal redox state of cells can cause toxic effects through the production of peroxides and free radicals that damage all components of the cell, including proteins, lipids, and DNA. Oxidative stress from oxidative metabolism causes base damage, as well as strand breaks in DNA. Base damage is mostly indirect and caused by reactive oxygen species (ROS) generated, e.g. O2− (superoxide radical), OH (hydroxyl radical) and H2O2 (hydrogen peroxide).
Related Journals: Journal of Pollution Effects & Control, Journal of Bioengineering & Biomedical Science, Journal of Nutrition & Food Sciences, Biochemistry & Physiology, Journal of Traumatic Stress Disorders & Treatment, American Journal of Medicine, Oxidative Medicine and Cellular Longevity
Some metals are toxic when they form poisonous soluble compounds. In the case of such metals any measurable amount may have negative health effects. Often heavy metals are thought as synonymous, but lighter metals may also be toxic in certain circumstances, such as beryllium and lithium.The definition may also include trace elements when in abnormally high doses may be toxic.Most often the definition of toxic metals includes at least cadmium, manganese, lead, mercury and the radioactive metals.
Related Journals: Toxicology: Open Access, Journal of Heavy Metal Toxicity and Diseases, Translational Biomedicine, Occupational Medicine & Health Affairs, Cardiovascular Pharmacology: Open Access, Journal of Toxicology
It is the quality of being toxic to cells. Such toxic agents are an immune cell or some types of venom, e.g. from the puff adder or brown recluse spider. The cells may undergo necrosis, in which they lose membrane integrity and die rapidly as a result of cell lysis. Cytotoxicity assays are used in developing therapeutics that targets rapidly dividing cancer cells, for instance; or they can screen "hits" from initial high-throughput drug screens for unwanted cytotoxic effects before investing in their development as a pharmaceutical.
Related Journals: Journal of Drug Metabolism & Toxicology, Cancer Medicine & Anti Cancer Drugs, Journal of Carcinogenesis & Mutagenesis, Toxicology in Vitro,Applied In Vitro Toxicology , Cell Biology and Toxicology
Any substance or mixture of substances intended for preventing, destroying, or controlling any pest, including vectors of human or animal disease, unwanted species of plants or animals, causing harm during or otherwise interfering with the production, processing, storage, transport, or marketing of food, agricultural commodities, wood and wood products or animal feed stuffs, or substances that may be administered to animals for the control of insects, arachnids, or other pests in or on their bodies.Although pesticides have benefits, some also have drawbacks, such as potential toxicity to humans and other species.
It is the secondary metabolite produced by organisms of the fungus kingdom and is capable of causing disease and death in both humans and animals.The term 'mycotoxin' is usually reserved for the toxic chemical products produced by fungi that readily colonize crops.One mold species may produce many different mycotoxins, and several species may produce the same mycotoxin.The symptoms of mycotoxicosis depend on the type of mycotoxin; the concentration and length of exposure; as well as age, health, and sex of the exposed individual.
Related Journals: Fungal Genomics & Biology, Virology & Mycology, Journal of Medical Microbiology & Diagnosis, Journal of Infectious Diseases & Therapy, Mycotoxin Research,World Mycotoxin Journal,Journal of Fungi — Open Access Mycology Journal
Molecules that binds to an enzyme and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors.The binding of an inhibitor can stop a substrate from entering the enzyme's active site and/or hinder the enzyme from catalysing its reaction. Inhibitor binding is either reversible or irreversible.
Related Journals: Enzyme Engineering, Biochemistry & Physiology: Open Access, Molecular Biology: Open Access, Journal of Proteomics & Bioinformatics, Current Synthetic and Systems Biology, The Open Enzyme Inhibition Journal ,Journal of Enzyme Inhibition and Medicinal Chemistry
A member of the cytochrome P450 mixed-function oxidase system, which is involved in the metabolism of xenobiotic in the body. The CYP2 subfamily is responsible for the majority of P450-mediated drug metabolism in humans. While CYP2E1 itself carries out a relatively low number of these reactions and related enzymes CYP1A2 and CYP3A4 are responsible for the breakdown of a large number of toxic environmental chemicals and carcinogens that enter the body, in addition to basic metabolic reactions such as fatty acid oxidations.
Related Journals: Journal of Drug Metabolism & Toxicology, Journal of Pharmacokinetics & Experimental Therapeutics,Journal of Pharmacogenomics & Pharmacoproteomics , Journal of Bioequivalence & Bioavailability, Journal of Clinical & Medical Genomics, Pharmacogenomics Journal
The process whereby certain substances such as pesticides or heavy metals move up the food chain, work their way into rivers or lakes, and are eaten by aquatic organisms such as fish, which in turn are eaten by large birds, animals or humans. The substances become concentrated in tissues or internal organs as they move up the chain.
It is a hazard associated with some chemical substances that they will interfere in some way with normal reproduction; such substances are called reprotoxic. It includes adverse effects on sexual function and fertility in adult males and females, as well as developmental toxicity in the offspring. It is usual to take a practical definition, including several different effects which are unrelated to each other except in their outcome of lowered effective fertility.
Related Journals: Reproductive System & Sexual Disorders: Current Research, Journal of Drug Metabolism & Toxicology, Journal of Sexual and Reproductive Medicine,Reproductive Toxicology
Toxicity of nanomaterials because of quantum size effects and large surface area to volume ratio.The smaller they are, the greater their surface area to volume ratio and the higher their chemical reactivity and biological activity. The greater chemical reactivity of nanomaterials can result in increased production of reactive oxygen species (ROS), including free radicals. ROS production has been found in a diverse range of nanomaterials including carbon fullerenes, carbon nanotubes and nanoparticle metal oxides. ROS and free radical production is one of the primary mechanisms of nanoparticle toxicity; it may result in oxidative stress, inflammation, and consequent damage to proteins, membranes and DNA.
Related Journals: Journal of Nanomedicine & Biotherapeutic Discovery, Journal of Nanomedicine & Nanotechnology, Journal of Nanosciences: Current Research,Nano Research and Applications,Journal of Nanomaterials & Molecular Nanotechnology
Drug abuse is a patterned use of a drug in which the user consumes the substance in amounts or with methods which are harmful to themselves or others, and is a form of substance-related disorder. Drug abuse, including alcohol and prescription drugs, can induce symptoms which resembles mental illness.In some cases these substance induced psychiatric disorders can persist long after detoxification, such as prolonged psychosis or depression after amphetamine or cocaine abuse.
Related Journals: Journal of Addiction Research & Therapy, Journal of Alcoholism & Drug Dependence, International Journal of Neurorehabilitation, journal of substance abuse treatment, Journal of Drug Abuse, substance Abuse journal
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