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Tumor vascular embolization therapy triggered via BBR nanoparticle aggregation

EuroSciCon Conference on Nanotechnology & Smart Materials
October 04 -06 ,2018 Amsterdam , Netherlands

Tingting Zheng, Hanqing Liu, Yawen An, Ziqian Zhou, Jiapu Jiao, Azhen Hu, Minghua Li, Tao Pei, Tao Yu, Huanhuan Feng and Yun Chen

PKU-HKUST, China Peking University Shenzhen Hospital, China Peking University Shenzhen Graduate School, China Shenzhen Graduate School of Harbin Institute of Technology (HITSZ), China

ScientificTracks Abstracts: Nano Res Appl

DOI: 10.21767/2471-9838-C6-024

Abstract

Here we announce that berberine (BBR) nanostructure is a promising vascular embolization agent for tumour therapy. It has been reported that BBR contributes to tumour cells apoptosis by releasing reactive oxygen species (ROS) which triggers PI3K-AKT-mTOR signalling pathway. This triggering step succeeds with either focused laser beam (FLB) or focused ultrasound (FUS) under performances of photodynamic or sonodynamic therapy (PDT or SDT), respectively. Moreover, ultrasonic diagnosis shows that tumour vessels have been blocked after BBR-PDT or -SDT treatment in vivo. Further, we investigate what’s behind and results point to self-assembly of BBR nanostructure, from nano- to micro- and macro-size. Finally, tumour vascular embolization occurs. Amphiphilic BBR chlorate tends to assemble into randomly nanostructures at room temperature in aqueous. However, spherical BBR nanostructures increase with growing temperature and BBR nanoparticles (BBRNPs) tends to monodisperse when we perform FLB or FUS. After treatment, BBRNPs start to aggregate when temperature is going down. Morphology studies from dynamic light scattering (DLS), scanning electron microscopy and optical microscopy show that BBRNPs aggregation is continuously taking place and finally ends up with macro-scale floccules. Though BBR is a commonly known photo- or sono-sensitizer for ROS-tumour therapy, it is rarely reported about what is going on after PDT or SDT therapy. Therefore, here we address BBRNPs aggregates as a promising vascular embolization which can assist PDT or SDT cancer therapy in preclinical studies

Biography

Tingting Zheng has obtained her PhD degree from Leiden University in Dec’ 2014 and continued with Postdoctoral studies at Wageningen University. She is currently an Associate Professor at Peking University Shenzhen Hospital. She has published more than 25 papers in top journals and has been serving as an Editor of Open Chemistry since 2015.

E-mail: [email protected]

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