Journal of Clinical and Molecular Endocrinology

The weight reduction in adolescents with Polycystic Ovarian Syndrome is associated with increase in serum adinopectin

4^th World Congress on Polycystic Ovarian Syndrome
June 07-08, 2018 London, UK

Omu AE, Al-Saeed B, Behbehani A and A-Azemi MK

Department of Obstetrics and Gynecology, Faculty of Medicine Kuwait University and Maternity Hospital, Kuwait

Posters & Accepted Abstracts: J Clin Mol Endocrinol

DOI: 10.21767/2572-5432-C1-003

Abstract

Introduction: Adiponectin is produced and expressed by adipose tissue, which is prevalent in Polycystic Ovarian Syndrome with increased Body Mass Index (BMI), Adiponectin has profound insulin – sensitizing, anti-inflammatory and anti-atherogenic effects. Objective of the study is to investigate the association between weight reduction in obese adolescents with PCOS and adiponectin and TNF-α and C-R-P. Patients and Methods: Twenty-seven adolescent women between 10 and 20 years with anovulation and hyperandrogenism were recruited from the outpatient clinic over a three year period September 1, 2014 to August 31, 2017. All had clinical evaluation including history and physical examination – weight and height and Body Mass Index.  They were randomized into 3 treatment groups: Metformin only, Metformin and Exercise and Exercise only. Serum levels of adinopectin, TNF-α, and C-reactive protein were estimated by ELISA technique initially before treatment and repeated after 3 months of treatment.
Results:  The features of oligomenorrhoae, high BMI and acne like in other parts of the world.  All the three interventions resulted in weight reduction and regular menstruation in about 34% of the young women. Metformin with exercise had more significant effect in decreasing total 50% as compared to 28% with metformin only and 14% with exercise only. Similarly, Metformin with exercise had a more significant increase of adiponectin (3.42 Vs 8.48 P < 0.001) decrease of TNF-α (11.08 Vs 48.4 P <0.020) and C-RP (20.8 Vs 11.4 P<0.031). Conclusion: Weight reduction in Obese adolescents with PCOS is associated with increased level of adiponectin and decrease levels of TNF-α and C-Reactive Protein. Key words: Adolescent, Adiponectin, weight reduction, Metformin, Tumor Necrosis Factor Alpha.
 

Biography

Dr Alexander E. Omu is a Professor in Department of Obstetrics and Gynecology and Faculty of Medicine at Health Sciences’ Center (HSC), Kuwait University, Kuwait.

Email:omu@hsc.edu.kw