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Volume 8, Issue 6 J Neurol Neurosci
ISSN: 2171-6625 Neuro, an open access journal Neuroscience 2017
October 16-17, 2017
OCTOBER 16-17, 2017 OSAKA, JAPAN
17TH Global Neuroscience Conference
The usefulness of combined brain perfusion SPECT, DAT-SPECTandMIBG scintigraphy for the diagnosis
of dementia with Lewy bodies
Seiju Kobayashi1,2 , Kanae Makino2, Shigeki Hatakeyama2, Tomo Iwamoto 2, Hanako Tsujino2, Wataru Ukai2, Eri Hashimoto2, Kumiko Utsumi3 and Chiaki
Kawanishi2
1Nakae Hospital, Japan
2Sapporo Medical University, Japan
3Sunagawa City Medical Center, Japan
Background&Aim: Current diagnostic criteria recommend neuroimaging as a diagnostic support tool for the clinical diagnosis
of dementia with Lewy bodies (DLB). Because DLB causes characteristic impairments and disabilities, such as neuroleptic
hypersensitivity, which may significantly increase morbidity and mortality, its prompt and correct diagnosis is very important.
The aim of this study was to evaluate the extent with which diagnostic accuracy can be increased using a combination of brain
perfusion SPECT (bp-SPECT), I-metaiodobenzylguanidine Myocardial Scintigraphy (MIBG scintigraphy) and DAT-SPECT.
Taking finances and patient burden into consideration, we compared the tests to determine priority.
Methods: 34 patients with probable DLB (75.0±8.3 years old, 14 male: 20 female) underwent bp-SPECT, MIBG myocardial
scintigraphy and DAT-SPECT.
Results: Our comparison of three functional imaging techniques indicated that MIBG scintigraphy (79%) or DAT-SPECT
(79%) had better sensitivity for characteristic abnormalities in DLB than bp-SPECT (53%). The combination of the three
modalities could increase sensitivity for diagnosis of DLB to 100%. Additionally the ratio of patients with rapid eye movement
sleep behavior disorder (RBD) was significantly higher in MIBG (+) group than in MIBG (-) group.
Conclusions: In the stand-alone diagnostic means, priority should be placed on MIBG scintigraphy or DAT-SPECT for the
diagnosis of DLB. However, our results suggest that the combination of bp-SPECT, MIBG scintigraphy and DAT-SPECT
increased accuracy of the clinical diagnosis of DLB.
Biography
Seiju Kobayashi is currently the Director of the Department of Psychiatry and also a Faculty of Medicine at Nakae Hospital, Japan.
Seiju Kobayashi et al., J Neurol Neurosci 2017, 8:6
DOI: 10.21767/2171-6625-C1-006