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.com
Volume 8, Issue 6
J Neurol Neurosci
ISSN: 2171-6625 Neuro, an open access journal
Neuroscience 2017
October 16-17, 2017
OCTOBER 16-17, 2017 OSAKA, JAPAN
17
TH
Global Neuroscience Conference
Combined effect of Baclofen and Acamprosate in experimental models of peripheral neuropathic
pain in Wistar rats
Varun Vikas Vij
Dayanand Medical College & Hospital, India
N
europathic Pain (NP) is defined as pain associated with damage or permanent alteration of the peripheral or central
nervous system. Current drug treatment for the management of neuropathic pain associated with various adverse effects.
The present study was designed to investigate the combined effect of Acamprosate and baclofen in experimental model of
peripheral Neuropathic pain in Wistar rats. Neuropathic pain was induced by chronic constriction injured (cci) of sciatic
nerve in rats. Acamprosate (100 and 200 mg/kg p.o) and Baclofen (10 and 20 mg/kg p.o) was given in different groups for 14
days starting on 7th day post sciatic nerve ligation. Further combination of Acamprosate (100 mg/kg p.o) and Baclofen (10
mg/kg p.o) was also given to one group. On 1
st
, 3
rd
, 7
th
, 14
th
and 21
st
day behavioral parameters like mechanical allodynia and
thermal hyperalgesia were assessed. Then animals were sacrificed on 22
nd
day and biochemical parameters (GSH, LPO, catalase,
nitrite, SOD) were assessed. Ligation of sciatic nerve significantly induced mechanical allodynia and thermal hyperalgesia
with increase in oxidative stress (increase in lpo and nitrite) and decline of anti-oxidant enzyme levels (catalase, SOD, GSH)
in sciatic nerve homogenate. Acamprosate (100 and 200 mg/kg p.o) and Baclofen (10 and 20 mg/kg p.o) attenuated all the
behavioral and biochemical parameters alone and/or combination.
Varunkumar1982dec@gmail.comJ Neurol Neurosci 2017, 8:6
DOI: 10.21767/2171-6625-C1-006