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Volume 8, Issue 6
J Neurol Neurosci
ISSN: 2171-6625 Neuro, an open access journal
Neuroscience 2017
October 16-17, 2017
OCTOBER 16-17, 2017 OSAKA, JAPAN
17
TH
Global Neuroscience Conference
Interaction between 5-HT4 and CB1 function in the pre-limbic cortex on memory consolidation
deficit in inhibitory avoidance task
Nargol Ahmadi-Mahmoodabadi
1
, Mohammad Nasehi
1
, Masoumeh Emamghoreishi
1
and Mohammad-Reza Zarrindast
1,3
1
Institute for Cognitive Science Studies, Iran
2
Shiraz University of Medical Sciences, Iran
3
Tehran University of Medical Sciences, Iran
T
his study performed to investigate the influence of bilateral post-training intra-pre limbic (PL) microinjections of
serotonergic 5-HT4 receptor agents (RS67333, as a 5-HT4 receptor agonist and RS23597-190, as a 5-HT4 receptor
antagonist) upon amnesia induced by a cannabinoid CB1 receptor agonist, Arachidonylcyclopropylamide (ACPA) in rats.
The step-through Inhibitory Avoidance (IA) and open filed apparatuses were used to examine the memory consolidation
and locomotion behaviors, respectively. Bilateral guide-cannulae were implanted to allow intra-PL microinjections of the
drugs. Also, post-training administration of the drugs was performed with the volume of 0.6 μl/rat (0.3 μl/side). Based on our
findings, post-training bilateral intra-PL microinjection of ACPA (0.1 and 0.5 µg/rat) decreased, whereas RS67333 (0.5 μg/rat)
increased IA memory consolidation. Meanwhile, post-training bilateral intra-PL administration of RS23597-190 (0.005, 0.01,
0.1 and 0.5 μg/rat) did not alter memory consolidation. Moreover, intra-PL micro-infusion of RS67333 (0.005 μg/rat) plus the
lower (0.001 µg/rat) or the higher (0.1 µg/rat) dose of ACPA potentiated or restored the memory consolidation impairment
induced by ACPA, respectively. While, post-training administration of RS23597-190 (0.5 μg/rat) plus the higher dose of ACPA
(0.1 μg/rat) potentiated the ACPA response. However none of the above interventions affect locomotors activity. In conclusion,
our results suggest that the PL 5-HT4
dr.ahmadi2012@gmail.comJ Neurol Neurosci 2017, 8:6
DOI: 10.21767/2171-6625-C1-006