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Volume 8, Issue 6 J Neurol Neurosci
ISSN: 2171-6625 Neuro, an open access journal Neuroscience 2017
October 16-17, 2017
OCTOBER 16-17, 2017 OSAKA, JAPAN
17TH Global Neuroscience Conference
Carvacrol protects against 6-OHDA toxicity in a PC12 inducible cell model for Parkinsonism
Mahboubeh Manouchehrabadi1 , Torkaman-Boutorabi A2 and Farhadi M1
1Islamic Azad University, Iran
2Tehran University of Medical Sciences, Iran
Parkinson's Disease (PD) is a progressive neurodegenerative movement disorder characterized by selective loss of
dopaminergic neurons and the presence of Lewy bodies. Treatment for PD that prevents neuronal death in the
dopaminergic system and abnormal protein deposition in the brain is not yet available. Evidence from human and animal
studies has suggested that oxidative damage critically contributes to neuronal loss in PD. This study aimed to evaluate the
potential neuroprotective effects of carvacrol on PC12 cells treated with 6-OHDA, a cellular model of Parkinson's disease.
Carvacrol, a naturally occurring monoterpenic phenol and food additive, has been shown to have antimicrobials, antitumor,
neuroprotective and antidepressant like activities. We found that carvacrol protect against 6-OHDA induced cell death in a
dose-dependent manner. Neuroprotection was found to coincide with increasing cell viability and reductions in intracellular
reactive oxygen species and lipid peroxidation. This study demonstrates that carvacrol protected against 6-OHDA induced
cell death via inhibition of oxidative stress, suggesting that carvacrol may be a candidate neuroprotective agent for 6-OHDA
induced Parkinsonism and possibly for other genetic or sporadic forms of PD.
Biography
Mahboubeh Manouchehrabadi is currently pursuing MSc in Developmental Biology from Islamic Azad University of Karaj, Iran. She is expert in experimenting in
vitro and in vivo models of Parkinson’s disease.
Mahboubeh Manouchehrabadi et al., J Neurol Neurosci 2017, 8:6
DOI: 10.21767/2171-6625-C1-006