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Abstract

Synthesis and Characterization of Hybrid Compounds for the Treatment of Bone Related Diseases

Bone diseases are major causes of abnormalities of the human skeletal system. To mention a few, osteoporosis, osteogenesis imperfecta and bone cancer are examples. This study is mainly focusing on osteoporosis and bone cancer. Osteoporosis have claimed many lives and some call it a silent thief because it has no clinical manifestations until there is a fracture. Bone cancer is also a life threating disease due to its effect of reducing red blood cell level. Bisphosphonates are well known antiresorptive drugs with the ability to inhibit the bone resorption process and diethylenetriamine compounds are chelating agents which can be used in chemotherapy to inhibit proliferation of several human cancers. So, the current research is aiming to make one more step in chemistry of hybrid compounds with high potency, high efficacy and low toxicity. All the reactions were performed at room temperature then, infrared and nuclear magnetic resonance were used to characterize the synthesized compounds.


Author(s): Victar Nyaarugwe*

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