Simple and Multi-Component Synthesis of Pyrrole Heterocycles

Pyrroles is the special class of heterocyclic compounds with a broad spectrum of biological activities such as anti-inflammatory, antiproliferative, antihistaminic, anti-HIV, antifungal, antihelmintic and antiviral agents. Pyrrole is a five membered ring structure, with formula C₄H₄NH. The heterocyclic pyrroles are the ideal building blocks for different biologically efficient molecules including porphyrins and bile pigments. Therefore researchers are synthesizing these heterocycles through multi-stepped or single stepped pathways as target structures for biological studies. In this review, different synthetic protocols/methodologies are shown in which different entry molecules are converted into pyrrole derivatives, which are important from medicinal and pharmaceutical points of view.

Author(s): Ayaz Mahmood Dar, Shafia Mir, Hilal Ul Zaman, Javid Ahmad Lone, Hena Khanam, Muzaff and Kouncer Hassan

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