Safety of Gliclazide With the Aqueous Extract of Gymnema Sylvestre on Pharmacodynamic Activity in Normal and Alloxan Induced Diabetic Rats

The present study was carried out to evaluate the hypoglycemic activity and antihyper glycemic activity of aqueous extracts of whole plant of Gymnema sylvestre in normal and in alloxan induced diabetic rats. The aqueous extract of Gymnema sylvestre (30mg/Kg, 100mg/Kg, 300mg/Kg b.w.) and the dose (100mg/Kg) that produced an optimal reduction (30-40%) of blood glucose was selected for the study. Blood samples were collected at desired intervals of time and analyzed for blood glucose by the GOD - POD method. Gliclazide a second generation sulfonyl urea was selected for the interaction study with that of the Gymnema sylvestre. The doses of Gliclazide (1mg/Kg, 2mg/Kg and 4mg/Kg b.w.) were given to normal and diabetic rats and the dose (2mg/Kg b.w.) that produced an optimal reduction of blood glucose was selected for the study. The prior administration of Gymnema sylvestre significantly increased the hypoglycemic and antihyperglycemic activity of Gliclazide.

Author(s): M. Ganga Raju, S. Satyanarayana and Eswar Kumar

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